Aquablation for Benign Prostatic Hyperplasia in Large Prostates

OBJECTIVE

To report 12-month safety and effectiveness outcomes of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume prostates.

METHODS

One hundred and one men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent a robotic-assisted Aquablation procedure in a prospective multicenter international clinical trial. Functional and safety outcomes were assessed at 12 months postoperatively.

RESULTS

Mean prostate volume was 107 cc (range 80-150). Mean operative time was 37 minutes and mean Aquablation resection time was 8 minutes. The average length of hospital stay following the procedure was 1.6 days. Mean International Prostate Symptom Score improved from 23.2 at baseline to 6.2 at 12 months (P <.0001). Mean International Prostate Symptom Score quality of life improved from 4.6 at baseline to 1.3 at 12-month follow-up (P <.0001). Significant improvements were seen in Qmax (12-month improvement of 12.5 cc/sec) and postvoid residual (drop of 171 cc in those with postvoid residual >100 at baseline). Antegrade ejaculation was maintained in 81% of sexually active men. No patient underwent a repeat procedure for BPH symptoms. There was a 2% de novo incontinence rate at 12 months, and 10 patients did require a transfusion postoperatively while 5 required take back fulgurations. At 12 months, prostate-specific antigen reduced from 7.1 ± 5.9 ng/mL at baseline to 4.4 ± 4.3 ng/mL.

CONCLUSION

The Aquablation procedure is demonstrated to be safe and effective in treating men with large prostates (80-150 cc) after 1 year of follow-up, with an acceptable complication rate and without a significant increase in procedure or resection time compared to smaller sized glands.

You Might Also Enjoy...

Understanding Male Menopause

Menopause is a process that every woman experiences with age, but did you know hormonal imbalance (and its symptoms) aren’t just a women’s health issue? Male menopause is triggered by low testosterone, and it can impact your life in a number of ways.

How the O-Shot® Can Improve Your Sex Life

Low sex drive. Painful intercourse. Inability to orgasm. Sound familiar? You could be suffering from sexual dysfunction. It’s a real condition, and it’s treatable. Find out how the O-Shot® — a platelet-rich plasma therapy — could help you.

My Hormones Are Out of Balance

Hormones are important chemical messengers in your body. When they’re out of balance, you could experience a range of unpleasant symptoms. Learn the signs of hormone imbalance and what you can do to relieve your symptoms.

Help! I'm Struggling With Low Libido

Low libido can make you feel embarrassed, frustrated, and angry. It’s a common problem, but you don’t have to accept it. Learn more about sexual dysfunction, what causes it, and how you can treat it to revitalize your sex life.

Can Any Medicine Help With Peyronie's Disease?

If you have Peyronie’s disease, you’re likely all too familiar with the curved, painful erections it causes. Peyronie’s disease can hinder your self-esteem and your sex life, but it’s treatable. Find out if prescription XIAFLEX® is right for you.

Are You Suffering From Vaginismus?

Vaginismus commonly makes vaginal penetration painful or impossible. If you can’t have penetrative sex, use tampons, or get pelvic exams, you could be suffering from vaginismus. Learn more about it and find treatment here.