Skip to main content

Can Peyronie’s Disease Patients Benefit from Multiple Rounds of Xiaflex Injections?

Peyronie’s disease (PD) is a sexual health condition that affects up to 13% of the adult men in the United States. In men with PD, plaques of scar tissue form under the skin of the penis, causing it to curve or take on a deformity when it is erect. This can lead to painful erections, erectile dysfunction (ED), low self-esteem, mental health issues, and relationship difficulties.

Intralesional collagenase clostridium histolyticum injection therapy (Xiaflex) is an FDA-approved treatment for PD. The medication, which is injected into the penis by a trained health care professional, works by breaking down some of the components of the plaques that are causing the penis to bend.

Previous clinical trials for Xiaflex have outlined the protocol as follows: 8 injections divided into 4 treatment cycles of 2 injections separated by a few days. Results from one such study showed an average improvement in curve deformity of 34% after the patients received all 8 injections.

According to the experts, clinical improvement is defined as a 20% decrease in penile curvature after treatment. However, patients who don’t reach clinical improvement after 1 round of Xiaflex may question whether additional rounds of treatment would be beneficial.

A recent study sought to answer this question by analyzing the results of all patients receiving Xiaflex injections at a single institution between October 2015 and December 2020. Some of the patients who completed 1 round of treatment opted to complete additional rounds of treatment, receiving either 16 or 24 injections overall.

For this study, the authors had access to the pre- and posttreatment erect penile curvature measurements of 229 patients who completed 1 round of treatment, 80 who completed 2 rounds of treatment, and 18 who completed 3 rounds of treatment.

In total, 57 of the 80 patients who had a second round of treatment and 8 of the 18 who had a third did not achieve clinical improvement after their previous round. Ultimately, 42.8% (98/229), 38.6% (22/57), and 12.5% (1/8) of patients achieved clinical improvement after 1, 2, and 3 rounds of therapy, respectively.

Furthermore, the average percentage of penile curvature improvement was 16.4% after 1 round, 16.8% after 2 rounds, and 8.1% after three rounds. The most frequent side effect was bruising, but swelling and penile blood blisters were also common.

Given these results, the researchers concluded that for patients who do not reach clinical improvement after 1 round of treatment, an additional round may be beneficial. On the other hand, a third round showed no significant improvements.


You Might Also Enjoy...

5 Factors That Fuel Erectile Dysfunction

Erectile dysfunction (ED) can prevent you from having the sex life you desire. But although it can be embarrassing, it’s also treatable. Learn about common factors that increase your risk of ED and what you can do to improve your health.

Why Can't I Have an Orgasm?

Everyone deserves a satisfying sex life. And if you can’t orgasm, sexual activity can be frustrating and embarrassing. Instead of suffering in silence, it’s time to learn more about sexual dysfunction and the treatment options to fix it.

What Can I Do About My Impotence?

Struggling to perform in the bedroom is embarrassing. But if you have problems getting or maintaining an erection, you’re not alone. Millions of men suffer from impotence — and treatment can help. Learn what your treatment options are here.

Understanding Male Menopause

Menopause is a process that every woman experiences with age, but did you know hormonal imbalance (and its symptoms) aren’t just a women’s health issue? Male menopause is triggered by low testosterone, and it can impact your life in a number of ways.

How the O-Shot® Can Improve Your Sex Life

Low sex drive. Painful intercourse. Inability to orgasm. Sound familiar? You could be suffering from sexual dysfunction. It’s a real condition, and it’s treatable. Find out how the O-Shot® — a platelet-rich plasma therapy — could help you.

My Hormones Are Out of Balance

Hormones are important chemical messengers in your body. When they’re out of balance, you could experience a range of unpleasant symptoms. Learn the signs of hormone imbalance and what you can do to relieve your symptoms.